▷ Editor’s Choice in Nutrients — Recognition for Clinical Research on Pomanox®

We are proud to share that the publication:

“Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55–70 Years: A Randomised Controlled Parallel Trial”

has been selected as an Editor’s Choice Article in Nutrients (MDPI).

Editor’s Choice Articles are selected by the journal’s editorial board to highlight work of particular scientific quality, originality, and relevance within the field.
This recognition represents independent acknowledgment of methodological rigor and translational significance.

This study was led by Dr Grace Farhat and her team at Manchester Metropolitan University, whose careful clinical execution and focus on healthspan biology underpin the strength of these findings.

Pomanox® is a patented pomegranate (Punica granatum L.) extract produced via Euromed’s Pure-Hydro Process®, a water-based, solvent-free extraction technology that preserves the fruit’s natural polyphenol profile. Its HPLC fingerprint mirrors the native fruit composition, providing substrates for microbial conversion into urolithins and linking polyphenol metabolism to mitochondrial and vascular resilience.

The 12-Week Manchester Trial (740 mg/day)

In adults aged 55–70 years:

✔️ Significant reductions in IL-6 (p = 0.02) and IL-1β (p = 0.05)
✔️ –5.2 mmHg reduction in systolic blood pressure (p = 0.04)
✔️ Downward trends in CRP and TNF-α

A 5 mmHg reduction in systolic blood pressure is associated with ~10% lower cardiovascular risk, even in non-hypertensive individuals.

Together, these results indicate measurable attenuation of inflammaging, supporting vascular efficiency and systemic balance during aging.

The paper has already surpassed 15,000 reads highlighting the growing interest in evidence-based healthspan solutions like Pomanox®.

Part of a Broader Clinical Program

Additional peer-reviewed publications from the same trial reported:

• Moderate restoration of IGF-1 within physiological range (+14 ng/mL, p = 0.04)
• 20% fewer errors in the Wisconsin Card Sorting Test (p = 0.05), reflecting improved executive function

These outcomes connect inflammatory balance, endocrine homeostasis, vascular flexibility, and cognition, aligning with mechanistic evidence linking Pomanox® to AHR–Nrf2–Akt/eNOS pathways

We thank Dr Farhat and her team for their outstanding contribution to advancing evidence-based botanical science.

LINK TO THE STUDY

5/5 - (1 vote)

Andrea

Scientific Communication Advisor at Euromed S.A.

Category	Study Type	Study Findings	Reference	Link
Cardiovascular & Metabolic Health	Animal Study – Endothelial Function	Preserved endothelial function and lower oxidative markers in hypercholesterolemic pigs.	Rev Esp Cardiol. 2015;68(3):216–25.	https://doi.org/10.1016/j.rec.2014.04.021
	Animal Study – Fructose-Fed Rat Model	Lower fat accumulation, microbiota shifts, and urolithin-like metabolites in fructose-fed rats.	Food Funct. 2024;15:7348–7363.	https://doi.org/10.1039/d4fo00688g
	Clinical Study – Cardiometabolic Health	Lower systolic BP, reduced cortisol, and higher quality-of-life scores.	EC Nutr. 2015;2:396–411.	https://www.researchgate.net/publication/341119964
	Clinical Study – Antioxidant Markers	Lower blood pressure and cortisol, higher antioxidant capacity, and urolithin A.	Antioxidants. 2022;11:2124.	https://doi.org/10.3390/antiox11112124
	Clinical Study – Blood Pressure	Lower diastolic blood pressure after 8 weeks.	J Nutr Sci. 2017;6:e39.	https://doi.org/10.1017/jns.2017.36
Healthy Aging	In Vivo – Longevity & AHR Pathway	Extended lifespan in C. elegans; AHR pathway activation in mouse liver.	Int J Mol Sci. 2024;25:9943.	https://doi.org/10.3390/ijms25189943
	Animal Study – Oxidative Stress in Aging Mice	Reduced basal ROS, protected WBC from induced oxidative damage, improved redox balance.	Int J Mol Sci. 2025;26:5957.	https://doi.org/10.3390/ijms26135957
	Clinical Study – IGF-1 & Telomere Biology	Moderate rise in circulating IGF-1; telomere length maintained over 12 weeks.	Nutrients. 2025;17:2974.	https://doi.org/10.3390/nu17182974
Sports Nutrition	Clinical Study – Endurance Performance	Improved time to exhaustion and post-exercise muscle recovery.	Nutrients. 2019;11:721.	https://doi.org/10.3390/nu11040721
Cognition & Behaviour	Animal Study – Frailty Prevention	Improved coordination and neuromuscular function, with lower oxidative damage in aging mice.	Antioxidants. 2023;12:1991.	https://doi.org/10.3390/antiox12111991
	Clinical Study – Acute Cognitive Performance	Faster logical reasoning and improved working-memory performance.	Academic Press; 2021. Chapter 10.	https://doi.org/10.1016/B978-0-12-820593-8.00010-0
	Clinical Study – Satiety & Eating Behaviour	Higher satiety ratings and reduced food intake during a test meal.	Foods. 2022;11:2639.	https://doi.org/10.3390/foods11172639
	Clinical Study – Cognitive Function (55–70 Years)	20% fewer WCST errors; trends toward improved memory and inhibitory control.	Geriatrics. 2025;10:29.	https://doi.org/10.3390/geriatrics10010029
Healthy Inflammatory Response	In Vitro – Inflammasome Activation	Reduced IL-1β release in ATP-stimulated macrophages.	Cell Death Differ. 2016;23:1219–31.	https://doi.org/10.1038/cdd.2015.176
	In Vitro – Corneal Epithelium Model	Lower IL-8 release and higher cell viability in LPS-stimulated corneal epithelial cells.	J Clin Transl Ophthalmol. 2023;1:52–60.	https://doi.org/10.3390/jcto1020007
	Animal Study – TNF-α–Induced Muscle Catabolism	Maintained muscle mass and reduced inflammatory signalling in TNF-α–challenged mice.	Mol Nutr Food Res. 2017;61:1600169.	https://doi.org/10.1002/mnfr.201600169
	Clinical Study – Cytokines & Cardiometabolic Health	Lower IL-6 and IL-1β, with trends in CRP, TNF-α, and systolic BP.	Nutrients. 2025;17:1235.	https://doi.org/10.3390/nu17071235
Skin Health	In Vitro – Photoaging Effects	Reduced UV-induced ROS, enhanced collagen and HA metabolism, and tyrosinase inhibition.	Int J Food Sci Nutr. 2022;74:51–63.	https://doi.org/10.1080/09637486.2022.2152189
Microbial Response	In Vitro – Antimicrobial Activity Assays	Bactericidal and antifungal effects against tested microorganisms.	Int J Mol Sci. 2024;25:6943.	https://doi.org/10.3390/ijms25136943
Gut Health	In Vitro – Proof of Concept	Punicalagin converted into ellagic acid by selected probiotics (urolithin precursor formation).	J Agric Food Chem. 2022;70:16273–16285.	https://doi.org/10.1021/acs.jafc.2c06585

Study Type	Key Findings	Reference
In-vivo Safety Study (Genotoxicity)	No mutation induced. Safe dose: 30mg/day or 2000mg/kg (single dose)	Mutation Research 777 (2015)
Subchronic Toxicity (13 weeks)	No toxicological effect up to 500mg/kg/day	Food Chem Toxicol 84 (2015)
Antimicrobial In-vitro Study	Antibacterial activity (E. coli, S. aureus) and antioxidant packaging effects	Foods 2020, 9, 1339
Human Study (15mg/day, 3 weeks)	Improved body composition, antioxidant status, gene expression (inflammation/oxidative stress)	Oxid Med Cell Longev. 2017
Antioxidant, CV Support (acute dose)	Strong antioxidant effect, reduced lipid peroxidation, SOD up-regulation	Biomedicine & Prevention 2017
Breast Cancer Patients (adjunct to chemo)	Reduced TIMP-1 levels, potential for improved prognosis	Antioxidants 2019, 8, 393
Exploratory Stroke Study (humans)	Reduced HbA1c, diastolic BP, improved neurological/functional outcomes	Int. J. Mol. Sci. 2024