ARTICHOKE FLOWER BUD – CYNAMED®

Cynamed® is an artichoke bud extract (Cynara scolymus L.) standardized to
caffeoylquinic acids (phenolic compounds) and inulin (soluble dietary fiber), naturally present in the artichoke bud.

This unique combination of ingredients, tested in a study, may promote prebiotic,digestive, and cardiometabolic well-being.

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Our artichokes are sustainably grown in Spain and processed at our Euromed facilities in Murcia, Spain, using the innovative Pure-Hydro Process® to produce Cynamed®. This water-only extraction technology preserves the natural properties of the artichoke while concentrating caffeoylquinic acids and inulin, whose solubility in the extraction water allows it to be obtained in higher concentrations compared to organic solvents.

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HEALTH PROPERTIES

Cardiovascular And Lipid Support

Digestive, Liver And Microbiome Health

Healthy Aging, Prevention

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Category	Study Type	Key Findings	Reference
Cardiovascular & Metabolic Health	Animal Study – Endothelial Dysfunction	Improved endothelial function, reduced vascular inflammation and oxidative stress	Rev Esp Cardiol (2015)
Cardiovascular & Metabolic Health	Animal Study – Metabolic Syndrome Prevention	Counteracted fructose-induced metabolic changes, improved liver health, gut microbiota	Food & Function 2024
Cardiovascular & Metabolic Health	Clinical Study – Risk Factors & QOL	Reduced blood pressure, glucose, cortisol; improved fat mass and life quality	EC Nutrition 2015
Cardiovascular & Metabolic Health	Clinical Study – CVD Risk & Antioxidants	Reduced blood pressure and cortisol, increased antioxidant markers (Urolithin A)	Antioxidants 2022
Cardiovascular & Metabolic Health	Clinical Study – Blood Pressure	Significant reduction in diastolic BP after 8 weeks	J Nutr Sci 2017
Sports Nutrition	Clinical Study – Cyclists’ Endurance	Improved time to exhaustion, reduced muscle damage & inflammation	Nutrients 2019
Cognition & Behaviour	Clinical Study – Cognitive Health	Improved memory, reasoning, attention and information processing	Academic Press 2021
Cognition & Behaviour	Clinical Study – Satiety	Increased satiety, reduced hunger and food intake post-meal	Foods 2022
Cognition & Behaviour	Animal Study – Frailty Prevention	Improved coordination and neuromuscular function, reduced oxidative damage in mice	Antioxidants 2023
Inflammation	In Vitro – IL-1β Inflammasome	Blocked IL-1β release in macrophages (ATP-treated), anti-inflammatory effect	Cell Death Differ 2016
Inflammation	In Vitro – Corneal Inflammation	Inhibited IL-8 release, outperformed dexamethasone; promoted cell viability	J Clin Transl Ophthalmol 2023
Inflammation	Animal Study – Muscle Loss Prevention	Prevented TNF-α-induced muscle loss, reduced oxidative stress, NF-kB inhibition	Mol Nutr Food Res
Skin Health	In Vitro – Photoaging Effects	Reduced ROS, boosted collagen and HA metabolism, tyrosinase inhibition	Int J Food Sci Nutr
Antimicrobial	In Vitro – Antimicrobial Activity	Outperformed ciprofloxacin against S. aureus in zone of inhibition	Int J Mol Sci 2024
Gut Health	In Vitro – Proof of Concept	Punicalagin transformed into ellagic acid & urolithins; potential gut support	J Agric Food Chem 2022
Antiaging	In Vivo – Longevity & AHR Pathway	Extended lifespan in C. elegans, activated AHR pathway in mice liver	Int J Mol Sci 2024

Study Type	Key Findings	Reference
In-vivo Safety Study (Genotoxicity)	No mutation induced. Safe dose: 30mg/day or 2000mg/kg (single dose)	Mutation Research 777 (2015)
Subchronic Toxicity (13 weeks)	No toxicological effect up to 500mg/kg/day	Food Chem Toxicol 84 (2015)
Antimicrobial In-vitro Study	Antibacterial activity (E. coli, S. aureus) and antioxidant packaging effects	Foods 2020, 9, 1339
Human Study (15mg/day, 3 weeks)	Improved body composition, antioxidant status, gene expression (inflammation/oxidative stress)	Oxid Med Cell Longev. 2017
Antioxidant, CV Support (acute dose)	Strong antioxidant effect, reduced lipid peroxidation, SOD up-regulation	Biomedicine & Prevention 2017
Breast Cancer Patients (adjunct to chemo)	Reduced TIMP-1 levels, potential for improved prognosis	Antioxidants 2019, 8, 393
Exploratory Stroke Study (humans)	Reduced HbA1c, diastolic BP, improved neurological/functional outcomes	Int. J. Mol. Sci. 2024