LEMON FRUIT DRY EXTRACT – WELLEMON®

Wellemon® is a lemon fruit extract (Citrus limon L.) standardized to the water-soluble flavanone eriocitrin.

In a human pharmacokinetic study, Wellemon®’s eriocitrin was found to be more bioavailable than hesperidin, producing up to 30 times higher concentrations of metabolites with potential health benefits for cardiometabolic, vascular, cognitive, and nutricosmetic applications.

CLICK TO READ THE STUDY

Our lemons are sustainably grown in Spain and processed at our Euromed facilities in Murcia, Spain, using the innovative Pure-Hydro Process® to produce Wellemon®. This water-only extraction technology preserves the natural properties of the lemon while concentrating eriocitrin and other flavanones.

Frequently asked questions (faqs)

Wellemon® is a proprietary lemon fruit extract (Citrus limon L.) standardized to lemon flavanones, particularly eriocitrin, a highly water-soluble and bioavailable flavanone naturally present in lemon. It is produced using Euromed’s Pure-Hydro Process®, a water-only extraction technology that preserves the natural profile of lemon bioactives without the use of organic solvents.

Wellemon® provides a clean-label, plant-based source of citrus polyphenols suitable for nutraceutical, functional food, and beverage applications.

Wellemon® is distinguished by its high content of eriocitrin, a lemon-derived flavanone known for its superior water solubility and bioavailability compared to other citrus polyphenols. The extract is produced using Euromed’s Pure-Hydro Process®, a water-only extraction method that preserves the natural profile of lemon bioactives without using organic solvents.

Wellemon® is also patented, ensuring a unique and standardized composition backed by robust scientific and technological development. Its excellent solubility, clean-label profile, and bioavailability make it highly versatile for nutraceutical and functional beverage formulations.

Wellemon® provides the well-known physiological properties of eriocitrin and lemon flavanones, including strong antioxidant activity, support for metabolic, vascular and skin wellness, and contributions to overall healthy aging.

A human pharmacokinetic study demonstrated that eriocitrin from Wellemon® produces up to 30 times higher circulating metabolite concentrations than hesperidin, indicating superior bioavailability and enhancing its potential physiological effects.

These features make Wellemon® a valuable ingredient for formulations targeting antioxidant protection, energy and vitality, metabolic balance, and general wellness.

Yes. Wellemon® is ideal for clean-label, vegan, and natural formulations. It is produced using Euromed’s Pure-Hydro Process®, a water-only extraction method that avoids organic solvents and preserves the native profile of lemon flavanones, including eriocitrin.

Thanks to its high water solubility, excellent organoleptic properties, and superior bioavailability, Wellemon® performs exceptionally well in functional beverages, ready-to-mix powders, dietary supplements, and general wellness formulations.

Do you want to know more about Wellemon®?

Get in Touch

Download Brochure PDF

HEALTH PROPERTIES

Antimicrobial Activity

Antioxidant activity

Blood Vessels, Circulation, Fluid Balance

Cardiovascular And Lipid Support

Glycemic Support

Healthy Aging, Prevention

Nutricosmetics, Hair And Skin Beauty

DOWNLOAD EUROMED PRODUCTS

Download PDF

5/5 - (4 votes)

Category	Study Type	Study Findings	Reference	Link
Cardiovascular & Metabolic Health	Animal Study – Endothelial Function	Preserved endothelial function and lower oxidative markers in hypercholesterolemic pigs.	Rev Esp Cardiol. 2015;68(3):216–25.	https://doi.org/10.1016/j.rec.2014.04.021
	Animal Study – Fructose-Fed Rat Model	Lower fat accumulation, microbiota shifts, and urolithin-like metabolites in fructose-fed rats.	Food Funct. 2024;15:7348–7363.	https://doi.org/10.1039/d4fo00688g
	Clinical Study – Cardiometabolic Health	Lower systolic BP, reduced cortisol, and higher quality-of-life scores.	EC Nutr. 2015;2:396–411.	https://www.researchgate.net/publication/341119964
	Clinical Study – Antioxidant Markers	Lower blood pressure and cortisol, higher antioxidant capacity, and urolithin A.	Antioxidants. 2022;11:2124.	https://doi.org/10.3390/antiox11112124
	Clinical Study – Blood Pressure	Lower diastolic blood pressure after 8 weeks.	J Nutr Sci. 2017;6:e39.	https://doi.org/10.1017/jns.2017.36
Healthy Aging	In Vivo – Longevity & AHR Pathway	Extended lifespan in C. elegans; AHR pathway activation in mouse liver.	Int J Mol Sci. 2024;25:9943.	https://doi.org/10.3390/ijms25189943
	Animal Study – Oxidative Stress in Aging Mice	Reduced basal ROS, protected WBC from induced oxidative damage, improved redox balance.	Int J Mol Sci. 2025;26:5957.	https://doi.org/10.3390/ijms26135957
	Clinical Study – IGF-1 & Telomere Biology	Moderate rise in circulating IGF-1; telomere length maintained over 12 weeks.	Nutrients. 2025;17:2974.	https://doi.org/10.3390/nu17182974
Sports Nutrition	Clinical Study – Endurance Performance	Improved time to exhaustion and post-exercise muscle recovery.	Nutrients. 2019;11:721.	https://doi.org/10.3390/nu11040721
Cognition & Behaviour	Animal Study – Frailty Prevention	Improved coordination and neuromuscular function, with lower oxidative damage in aging mice.	Antioxidants. 2023;12:1991.	https://doi.org/10.3390/antiox12111991
	Clinical Study – Acute Cognitive Performance	Faster logical reasoning and improved working-memory performance.	Academic Press; 2021. Chapter 10.	https://doi.org/10.1016/B978-0-12-820593-8.00010-0
	Clinical Study – Satiety & Eating Behaviour	Higher satiety ratings and reduced food intake during a test meal.	Foods. 2022;11:2639.	https://doi.org/10.3390/foods11172639
	Clinical Study – Cognitive Function (55–70 Years)	20% fewer WCST errors; trends toward improved memory and inhibitory control.	Geriatrics. 2025;10:29.	https://doi.org/10.3390/geriatrics10010029
Healthy Inflammatory Response	In Vitro – Inflammasome Activation	Reduced IL-1β release in ATP-stimulated macrophages.	Cell Death Differ. 2016;23:1219–31.	https://doi.org/10.1038/cdd.2015.176
	In Vitro – Corneal Epithelium Model	Lower IL-8 release and higher cell viability in LPS-stimulated corneal epithelial cells.	J Clin Transl Ophthalmol. 2023;1:52–60.	https://doi.org/10.3390/jcto1020007
	Animal Study – TNF-α–Induced Muscle Catabolism	Maintained muscle mass and reduced inflammatory signalling in TNF-α–challenged mice.	Mol Nutr Food Res. 2017;61:1600169.	https://doi.org/10.1002/mnfr.201600169
	Clinical Study – Cytokines & Cardiometabolic Health	Lower IL-6 and IL-1β, with trends in CRP, TNF-α, and systolic BP.	Nutrients. 2025;17:1235.	https://doi.org/10.3390/nu17071235
Skin Health	In Vitro – Photoaging Effects	Reduced UV-induced ROS, enhanced collagen and HA metabolism, and tyrosinase inhibition.	Int J Food Sci Nutr. 2022;74:51–63.	https://doi.org/10.1080/09637486.2022.2152189
Microbial Response	In Vitro – Antimicrobial Activity Assays	Bactericidal and antifungal effects against tested microorganisms.	Int J Mol Sci. 2024;25:6943.	https://doi.org/10.3390/ijms25136943
Gut Health	In Vitro – Proof of Concept	Punicalagin converted into ellagic acid by selected probiotics (urolithin precursor formation).	J Agric Food Chem. 2022;70:16273–16285.	https://doi.org/10.1021/acs.jafc.2c06585

Study Type	Key Findings	Reference
In-vivo Safety Study (Genotoxicity)	No mutation induced. Safe dose: 30mg/day or 2000mg/kg (single dose)	Mutation Research 777 (2015)
Subchronic Toxicity (13 weeks)	No toxicological effect up to 500mg/kg/day	Food Chem Toxicol 84 (2015)
Antimicrobial In-vitro Study	Antibacterial activity (E. coli, S. aureus) and antioxidant packaging effects	Foods 2020, 9, 1339
Human Study (15mg/day, 3 weeks)	Improved body composition, antioxidant status, gene expression (inflammation/oxidative stress)	Oxid Med Cell Longev. 2017
Antioxidant, CV Support (acute dose)	Strong antioxidant effect, reduced lipid peroxidation, SOD up-regulation	Biomedicine & Prevention 2017
Breast Cancer Patients (adjunct to chemo)	Reduced TIMP-1 levels, potential for improved prognosis	Antioxidants 2019, 8, 393
Exploratory Stroke Study (humans)	Reduced HbA1c, diastolic BP, improved neurological/functional outcomes	Int. J. Mol. Sci. 2024

LEMON FRUIT DRY EXTRACT – WELLEMON®

Frequently asked questions (faqs)

What is Wellemon®?+

What makes Wellemon® different from other citrus extracts?+

What health benefits are associated with Wellemon®?+

Is Wellemon® suitable for clean-label and natural formulations?+

Do you want to know more about Wellemon®?

HEALTH PROPERTIES

DOWNLOAD EUROMED PRODUCTS