OLIVE FRUIT EXTRACT – MEDITEANOX®

Mediteanox® is an olive fruit extract (Olea europaea L.) standardized to hydroxytyrosol, a powerful antioxidant compound known for its cardiovascular properties.

Clinically studied to promote antioxidant effects.

MEDITEANOX STUDIES

Our olives are sustainably grown in Spain and processed at our Euromed facilities in Murcia, Spain, using the innovative Pure-Hydro Process® to produce Mediteanox®. This water-only extraction technology preserves the natural properties of the olive while concentrating hydroxytyrosol.

Frequently asked questions (faqs)

Mediteanox® is a premium olive fruit extract (Olea europaea L.) standardized to hydroxytyrosol, one of the most powerful natural polyphenols found in olives. Produced using Euromed’s Pure-Hydro® Process, a purified-water extraction technology, Mediteanox® preserves the natural profile of olive antioxidants while delivering excellent purity and clean-label attributes. It is derived from sustainably sourced olives grown in Spain and provides a concentrated, consistent
source of hydroxytyrosol for use in nutraceutical, functional food, and healthy-aging formulations.

Mediteanox® stands out for its high and consistent hydroxytyrosol content, one of the most powerful polyphenolic antioxidants naturally present in olives. Hydroxytyrosol is also recognized in the European Union for its role in protecting LDL particles from oxidative damage at appropriate intake levels, underscoring the physiological relevance of this polyphenol. Mediteanox® is available with different concentrations of hydroxytyrosol.

In addition, Mediteanox® is self-affirmed GRAS, making it suitable for a wide range of food and beverage applications in the U.S. market.

Mediteanox® is patented and produced using Euromed’s Pure-Hydro® Process, a purified- water extraction technology that preserves the native profile of olive polyphenols while ensuring a clean-label, solvent-free ingredient.

Mediteanox® delivers the well-recognized physiological properties of hydroxytyrosol, including strong antioxidant activity and support for cardiometabolic wellness, cellular protection, and healthy aging. Hydroxytyrosol contributes to the protection of LDL particles from oxidative damage at intake levels specified by EFSA, highlighting its importance in oxidative-stress balance.

Mediteanox® has also been clinically tested in areas related to cardiometabolic function, antioxidant status, and aspects of central nervous system (CNS) support, including parameters linked to cognitive well-being and oxidative resilience.

Mediteanox® is produced using Euromed’s proprietary Pure-Hydro Process®, which uses only water as a solvent. This patented and eco-friendly method preserves the integrity of hydroxytyrosol and other bioactive compounds, ensuring a clean-label, solvent-free, and sustainable extract with high efficacy and safety. It is derived from sustainably cultivated Spanish olives and offers excellent water solubility, purity, and standardization.

Yes. Mediteanox® is fully suitable for clean-label, natural, and vegan formulations. It is produced using Euromed’s patented Pure-Hydro® Process, a purified-water extraction technology that avoids organic solvents and preserves the natural profile of hydroxytyrosol and other olive polyphenols.

The extract is plant-based, solvent-free, residue-free, and offers excellent purity and consistency, making it compatible with formulations that prioritize transparency, minimal processing, and sustainable sourcing across supplements, functional foods, and beverages.

Mediteanox® is highly versatile and suitable for a wide range of applications, including dietary supplements, functional foods, beverages, and healthy-aging formulations. Its standardized hydroxytyrosol content, excellent water solubility, and clean-label profile make it ideal for products targeting antioxidant support, cardiometabolic wellness, beauty from within, cellular protection, and overall vitality.

Mediteanox® can be incorporated into capsules, tablets, powders, ready-to-mix blends, shots, and liquid formulas, as well as premium functional food concepts where high-purity hydroxytyrosol is desired.

In addition, Euromed offers a patented technology and finished product that combines hydroxytyrosol with extra virgin olive oil (EVOO), marketed as Secret to Live®. This formulation delivers the EFSA-recommended intake of hydroxytyrosol in just 20 ml of Spanish EVOO, providing an easy, culinary-friendly way to achieve the physiological benefit associated with the protection of LDL particles from oxidative damage.

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HEALTH PROPERTIES

Antimicrobial Activity

Antioxidant activity

Cardiovascular And Lipid Support

Healthy Aging, Prevention

Immune Support

Nutricosmetics, Hair And Skin Beauty

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Category	Study Type	Study Findings	Reference	Link
Cardiovascular & Metabolic Health	Animal Study – Endothelial Function	Preserved endothelial function and lower oxidative markers in hypercholesterolemic pigs.	Rev Esp Cardiol. 2015;68(3):216–25.	https://doi.org/10.1016/j.rec.2014.04.021
	Animal Study – Fructose-Fed Rat Model	Lower fat accumulation, microbiota shifts, and urolithin-like metabolites in fructose-fed rats.	Food Funct. 2024;15:7348–7363.	https://doi.org/10.1039/d4fo00688g
	Clinical Study – Cardiometabolic Health	Lower systolic BP, reduced cortisol, and higher quality-of-life scores.	EC Nutr. 2015;2:396–411.	https://www.researchgate.net/publication/341119964
	Clinical Study – Antioxidant Markers	Lower blood pressure and cortisol, higher antioxidant capacity, and urolithin A.	Antioxidants. 2022;11:2124.	https://doi.org/10.3390/antiox11112124
	Clinical Study – Blood Pressure	Lower diastolic blood pressure after 8 weeks.	J Nutr Sci. 2017;6:e39.	https://doi.org/10.1017/jns.2017.36
Healthy Aging	In Vivo – Longevity & AHR Pathway	Extended lifespan in C. elegans; AHR pathway activation in mouse liver.	Int J Mol Sci. 2024;25:9943.	https://doi.org/10.3390/ijms25189943
	Animal Study – Oxidative Stress in Aging Mice	Reduced basal ROS, protected WBC from induced oxidative damage, improved redox balance.	Int J Mol Sci. 2025;26:5957.	https://doi.org/10.3390/ijms26135957
	Clinical Study – IGF-1 & Telomere Biology	Moderate rise in circulating IGF-1; telomere length maintained over 12 weeks.	Nutrients. 2025;17:2974.	https://doi.org/10.3390/nu17182974
Sports Nutrition	Clinical Study – Endurance Performance	Improved time to exhaustion and post-exercise muscle recovery.	Nutrients. 2019;11:721.	https://doi.org/10.3390/nu11040721
Cognition & Behaviour	Animal Study – Frailty Prevention	Improved coordination and neuromuscular function, with lower oxidative damage in aging mice.	Antioxidants. 2023;12:1991.	https://doi.org/10.3390/antiox12111991
	Clinical Study – Acute Cognitive Performance	Faster logical reasoning and improved working-memory performance.	Academic Press; 2021. Chapter 10.	https://doi.org/10.1016/B978-0-12-820593-8.00010-0
	Clinical Study – Satiety & Eating Behaviour	Higher satiety ratings and reduced food intake during a test meal.	Foods. 2022;11:2639.	https://doi.org/10.3390/foods11172639
	Clinical Study – Cognitive Function (55–70 Years)	20% fewer WCST errors; trends toward improved memory and inhibitory control.	Geriatrics. 2025;10:29.	https://doi.org/10.3390/geriatrics10010029
Healthy Inflammatory Response	In Vitro – Inflammasome Activation	Reduced IL-1β release in ATP-stimulated macrophages.	Cell Death Differ. 2016;23:1219–31.	https://doi.org/10.1038/cdd.2015.176
	In Vitro – Corneal Epithelium Model	Lower IL-8 release and higher cell viability in LPS-stimulated corneal epithelial cells.	J Clin Transl Ophthalmol. 2023;1:52–60.	https://doi.org/10.3390/jcto1020007
	Animal Study – TNF-α–Induced Muscle Catabolism	Maintained muscle mass and reduced inflammatory signalling in TNF-α–challenged mice.	Mol Nutr Food Res. 2017;61:1600169.	https://doi.org/10.1002/mnfr.201600169
	Clinical Study – Cytokines & Cardiometabolic Health	Lower IL-6 and IL-1β, with trends in CRP, TNF-α, and systolic BP.	Nutrients. 2025;17:1235.	https://doi.org/10.3390/nu17071235
Skin Health	In Vitro – Photoaging Effects	Reduced UV-induced ROS, enhanced collagen and HA metabolism, and tyrosinase inhibition.	Int J Food Sci Nutr. 2022;74:51–63.	https://doi.org/10.1080/09637486.2022.2152189
Microbial Response	In Vitro – Antimicrobial Activity Assays	Bactericidal and antifungal effects against tested microorganisms.	Int J Mol Sci. 2024;25:6943.	https://doi.org/10.3390/ijms25136943
Gut Health	In Vitro – Proof of Concept	Punicalagin converted into ellagic acid by selected probiotics (urolithin precursor formation).	J Agric Food Chem. 2022;70:16273–16285.	https://doi.org/10.1021/acs.jafc.2c06585

Study Type	Key Findings	Reference
In-vivo Safety Study (Genotoxicity)	No mutation induced. Safe dose: 30mg/day or 2000mg/kg (single dose)	Mutation Research 777 (2015)
Subchronic Toxicity (13 weeks)	No toxicological effect up to 500mg/kg/day	Food Chem Toxicol 84 (2015)
Antimicrobial In-vitro Study	Antibacterial activity (E. coli, S. aureus) and antioxidant packaging effects	Foods 2020, 9, 1339
Human Study (15mg/day, 3 weeks)	Improved body composition, antioxidant status, gene expression (inflammation/oxidative stress)	Oxid Med Cell Longev. 2017
Antioxidant, CV Support (acute dose)	Strong antioxidant effect, reduced lipid peroxidation, SOD up-regulation	Biomedicine & Prevention 2017
Breast Cancer Patients (adjunct to chemo)	Reduced TIMP-1 levels, potential for improved prognosis	Antioxidants 2019, 8, 393
Exploratory Stroke Study (humans)	Reduced HbA1c, diastolic BP, improved neurological/functional outcomes	Int. J. Mol. Sci. 2024

OLIVE FRUIT EXTRACT – MEDITEANOX®

Frequently asked questions (faqs)

What is Mediteanox®?+

What makes Mediteanox® different from other olive extracts?+

What health benefits are associated with Mediteanox®?+

How is Mediteanox® produced?+

Is Mediteanox® suitable for clean-label and vegan formulations?+

In which types of products can Mediteanox® be used?+

Do you want to know more about Mediteanox®?

HEALTH PROPERTIES

DOWNLOAD EUROMED PRODUCTS