| Cardiovascular & Metabolic Health |
Animal Study – Endothelial Dysfunction |
Improved endothelial function, reduced vascular inflammation and oxidative stress |
Rev Esp Cardiol (2015) |
| Cardiovascular & Metabolic Health |
Animal Study – Metabolic Syndrome Prevention |
Counteracted fructose-induced metabolic changes, improved liver health, gut microbiota |
Food & Function 2024 |
| Cardiovascular & Metabolic Health |
Clinical Study – Risk Factors & QOL |
Reduced blood pressure, glucose, cortisol; improved fat mass and life quality |
EC Nutrition 2015 |
| Cardiovascular & Metabolic Health |
Clinical Study – CVD Risk & Antioxidants |
Reduced blood pressure and cortisol, increased antioxidant markers (Urolithin A) |
Antioxidants 2022 |
| Cardiovascular & Metabolic Health |
Clinical Study – Blood Pressure |
Significant reduction in diastolic BP after 8 weeks |
J Nutr Sci 2017 |
| Sports Nutrition |
Clinical Study – Cyclists’ Endurance |
Improved time to exhaustion, reduced muscle damage & inflammation |
Nutrients 2019 |
| Cognition & Behaviour |
Clinical Study – Cognitive Health |
Improved memory, reasoning, attention and information processing |
Academic Press 2021 |
| Cognition & Behaviour |
Clinical Study – Satiety |
Increased satiety, reduced hunger and food intake post-meal |
Foods 2022 |
| Cognition & Behaviour |
Animal Study – Frailty Prevention |
Improved coordination and neuromuscular function, reduced oxidative damage in mice |
Antioxidants 2023 |
| Inflammation |
In Vitro – IL-1β Inflammasome |
Blocked IL-1β release in macrophages (ATP-treated), anti-inflammatory effect |
Cell Death Differ 2016 |
| Inflammation |
In Vitro – Corneal Inflammation |
Inhibited IL-8 release, outperformed dexamethasone; promoted cell viability |
J Clin Transl Ophthalmol 2023 |
| Inflammation |
Animal Study – Muscle Loss Prevention |
Prevented TNF-α-induced muscle loss, reduced oxidative stress, NF-kB inhibition |
Mol Nutr Food Res |
| Skin Health |
In Vitro – Photoaging Effects |
Reduced ROS, boosted collagen and HA metabolism, tyrosinase inhibition |
Int J Food Sci Nutr |
| Antimicrobial |
In Vitro – Antimicrobial Activity |
Outperformed ciprofloxacin against S. aureus in zone of inhibition |
Int J Mol Sci 2024 |
| Gut Health |
In Vitro – Proof of Concept |
Punicalagin transformed into ellagic acid & urolithins; potential gut support |
J Agric Food Chem 2022 |
| Antiaging |
In Vivo – Longevity & AHR Pathway |
Extended lifespan in C. elegans, activated AHR pathway in mice liver |
Int J Mol Sci 2024 |
