SPINACH LEAF EXTRACT – SPISAR®

Spisar® is a spinach leaf extract (Spinacia oleracea L.) standardized to ecdysteroids, natural adaptogenic compounds.

Clinically studied to support muscle strength and muscle quality.

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Our spinaches are sustainably grown in Spain and processed at our Euromed facilities in Murcia, Spain, using the innovative Pure-Hydro Process® to produce Spisar®. This water-only extraction technology preserves the natural properties of the spinach while concentrating ecdysteroids.

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HEALTH PROPERTIES

Cardiovascular And Lipid Support

Healthy Aging, Prevention

Joint Health

Sports Nutrition

Weight Management

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Pomanox® Studies

Category	Study Type	Key Findings	Reference
Cardiovascular & Metabolic Health	Animal Study – Endothelial Dysfunction	Improved endothelial function, reduced vascular inflammation and oxidative stress	Rev Esp Cardiol (2015)
Cardiovascular & Metabolic Health	Animal Study – Metabolic Syndrome Prevention	Counteracted fructose-induced metabolic changes, improved liver health, gut microbiota	Food & Function 2024
Cardiovascular & Metabolic Health	Clinical Study – Risk Factors & QOL	Reduced blood pressure, glucose, cortisol; improved fat mass and life quality	EC Nutrition 2015
Cardiovascular & Metabolic Health	Clinical Study – CVD Risk & Antioxidants	Reduced blood pressure and cortisol, increased antioxidant markers (Urolithin A)	Antioxidants 2022
Cardiovascular & Metabolic Health	Clinical Study – Blood Pressure	Significant reduction in diastolic BP after 8 weeks	J Nutr Sci 2017
Sports Nutrition	Clinical Study – Cyclists’ Endurance	Improved time to exhaustion, reduced muscle damage & inflammation	Nutrients 2019
Cognition & Behaviour	Clinical Study – Cognitive Health	Improved memory, reasoning, attention and information processing	Academic Press 2021
Cognition & Behaviour	Clinical Study – Satiety	Increased satiety, reduced hunger and food intake post-meal	Foods 2022
Cognition & Behaviour	Animal Study – Frailty Prevention	Improved coordination and neuromuscular function, reduced oxidative damage in mice	Antioxidants 2023
Inflammation	In Vitro – IL-1β Inflammasome	Blocked IL-1β release in macrophages (ATP-treated), anti-inflammatory effect	Cell Death Differ 2016
Inflammation	In Vitro – Corneal Inflammation	Inhibited IL-8 release, outperformed dexamethasone; promoted cell viability	J Clin Transl Ophthalmol 2023
Inflammation	Animal Study – Muscle Loss Prevention	Prevented TNF-α-induced muscle loss, reduced oxidative stress, NF-kB inhibition	Mol Nutr Food Res
Skin Health	In Vitro – Photoaging Effects	Reduced ROS, boosted collagen and HA metabolism, tyrosinase inhibition	Int J Food Sci Nutr
Antimicrobial	In Vitro – Antimicrobial Activity	Outperformed ciprofloxacin against S. aureus in zone of inhibition	Int J Mol Sci 2024
Gut Health	In Vitro – Proof of Concept	Punicalagin transformed into ellagic acid & urolithins; potential gut support	J Agric Food Chem 2022
Antiaging	In Vivo – Longevity & AHR Pathway	Extended lifespan in C. elegans, activated AHR pathway in mice liver	Int J Mol Sci 2024

Mediteanox Studies

Study Type	Key Findings	Reference
In-vivo Safety Study (Genotoxicity)	No mutation induced. Safe dose: 30mg/day or 2000mg/kg (single dose)	Mutation Research 777 (2015)
Subchronic Toxicity (13 weeks)	No toxicological effect up to 500mg/kg/day	Food Chem Toxicol 84 (2015)
Antimicrobial In-vitro Study	Antibacterial activity (E. coli, S. aureus) and antioxidant packaging effects	Foods 2020, 9, 1339
Human Study (15mg/day, 3 weeks)	Improved body composition, antioxidant status, gene expression (inflammation/oxidative stress)	Oxid Med Cell Longev. 2017
Antioxidant, CV Support (acute dose)	Strong antioxidant effect, reduced lipid peroxidation, SOD up-regulation	Biomedicine & Prevention 2017
Breast Cancer Patients (adjunct to chemo)	Reduced TIMP-1 levels, potential for improved prognosis	Antioxidants 2019, 8, 393
Exploratory Stroke Study (humans)	Reduced HbA1c, diastolic BP, improved neurological/functional outcomes	Int. J. Mol. Sci. 2024